Completed Studies

ADAPTT Comprehensive ascertainment of bleeding in patients prescribed different combinations of dual antiplatelet therapy (DAPT) and triple therapy (TT, DAPT plus an anticoagulant) after coronary interventions in the UK: a population based cohort study
ADEPT Guided Self-Help for Depression in adults with Autism: A feasibility RCT
AIRWAYS-2 Cluster randomised trial of the clinical and cost effectiveness of the i‐gel supraglottic airway device versus tracheal intubation in the initial airway management of out of hospital cardiac arrest
ARCADIA Association of non-coding RNAs with Coronary Artery Disease and type 2 Diabetes
AMIST A multicentre randomised controlled trial of minimally invasive direct coronary bypass grafting versus percutaneous transluminal coronary angioplasty with stenting for proximal stenosis of the left anterior descending coronary artery
BEE  Which is the best type of moisturiser to prescribe for treating the symptoms of childhood eczema – a lotion, cream, gel or ointment?
BHACAS 1&2  Early and midterm outcome after off-pump and on-pump surgery in Beating Heart Against Cardioplegic Arrest Studies (BHACAS 1 and 2): a pooled analysis of two randomised controlled trials 
BLUEBELLE A feasibility study of three wound dressing strategies in elective and unplanned surgery
CAIRO Improving Outcomes from Out of Hospital Cardiac Arrest: The Cardiac Arrest Individual Registry and Outcomes (CAIRO) Programme 
CHICO  Improving the treatment and care of children attending GP practices with coughs and acute respiratory tract infection (RTI)
CODEC Investigation of neural mechanisms of COgnitive DEcline after Cardiac surgery with resting state fMRI: A Pilot study 
COPTIC Coagulation and platelet laboratory testing in cardiac surgery 
COMICS Conventional versus Minimally Invasive extra-corporeal circulation in patients undergoing Cardiac Surgery: a randomised controlled trial 
CRISP Coronary artery grafting in High Risk patients randomised to Off Pump or On Pump Surgery 
CORTISOL Ultradian rhythms of cortisol after cardiac surgery
CORTISOL 2 Cortisol profiles in the critically ill after cardiac surgery
DECISION Detection of Coagulopathy in Paediatric Heart Surgery 
ECHOES The Effectiveness of Community versus Hospital Eye Service follow-up for patients with neovascular age-related macular degeneration with quiescent disease: a virtual trial 
ERICCA Effect of Remote Ischaemic preConditioning on clinical outcomes in patients undergoing Coronary Artery Bypass Graft surgery (ERICCA): A multicentre randomised controlled clinical trial 
EVALUATE Evaluation of multi parametric magnetic resonance imaging for characterising lymph node status, peritoneal and liver metastasis in pancreatic cancer 
EVARREST  A Single‐blinded, Randomized, Controlled, Comparative Phase III Study Evaluating the Safety and Effectiveness of EVARREST™ Fibrin Sealant Patch as an Adjunct to Hemostasis During Cardiovascular Surgery 
HARVEST  A randomised controlled trial to assess the extent of intimal Hyperplasia and Atherogenesis in bypass Vein grafts following different Surgical preparation Techniques
HepCATT  Evaluation of interventions designed to increase diagnosis and treatment of patients with Hepatitis C virus infection in primary care.
INFORM A multi-centered randomised trial to compare 1 stage with 2 stage revision surgery for prosthetic hip joint infection
IVAN A randomised controlled trial of alternative treatments to Inhibit VEGF in Age-related choroidal Neovascularisation (IVAN) 
IVAN Follow Up Five year observational follow-up of the IVAN trial cohort: a study of function and morphology
INVITE The effectiveness on post-operative recovery of using ‘off pump’ self-expanding tissue valves (IPVR) versus ‘on pump’ conventional tissue valves (PVR) for pulmonary valve replacement: an early phase randomised controlled trial (RCT) 
MAGENTA  Testing whether a treatment that we use for CFS/ME called “Graded Exercise Therapy” is effective and value for money.
MONARCH Monitoring for neovascular Age-related macular degeneration (AMD) Reactivation at Home 
MONITOR Effectiveness and cost-effectiveness of serum B-type natriuretic peptide (BNP or NT-BNP) testing and monitoring in patients with heart failure (HF) in primary and secondary care 
NAPSACC A feasibility cluster randomised controlled trial in child care settings to increase physical activity and healthy eating in 2-4 year olds  
OXFORD ARTERY Role of potassium channels in sustaining physiological responses of human resistance arteries
OXIC2 A randomised controlled trial to compare normoxic versus standard cardiopulmonary bypass in cyanotic children undergoing cardiac surgery
PASPORT Patient-specific cerebral oxygenation monitoring as part of an algorithm to reduce transfusion during heart valve surgery: a randomised controlled trial
PEACOCK Hypothalamic-pituitary-adrenal (HPA) axis: function and control mechanisms in children undergoing cardiac surgery 
PINPOINT A study of platelet inhibition, using a ‘point of care’ platelet function test, following primary percutaneous coronary intervention for ST elevation myocardial infarction 
PIPA Benefit to patients and the NHS of cardiac magnetic resonance imaging (CMR) after Primary percutaneous coronary Intervention (PPCI) Pathway Activation
PLAN-A Exercise intervention in adolescent girls
PROMIS Progenitor cell responsafter Myocardial Infarction Study 
PROMPT Propofol cardioplegia for Myocardial Protection Trial 
RADAR Reducing Alzheimer’s Disease through Angiotensin TaRgetting
 RAFT Reducing Arthritis Fatigue – clinical Teams using cognitive-behavioural approaches  
REST The Runny Ear Study (REST) will focus on children who have middle ear infections with discharge (AOMd) – please note this study is now closed to recruitment
 ROMIO  The Renoprotective value of Leukodepletion in Heart Valve surgery: an external feasibility randomised controlled trial
 ROLO  Randomised Oesophagectomy: Minimally Invasive or Open
 SIPS Surgical Interventions to treat Severe Pressure Ulcers
 SKARF Determination of the SK channel composition contributing to atrial action potential duration and of predictors of response to treatments in patients with or without atrial fibrillation
 STAR Support and Treatment After Knee Replacement
STET A randomised controlled trial of median sternotomy vs. anterolateral left thoracotomy on morbidity and healthcare resource use in patients having off-pump coronary artery bypass surgery 
TARGET Randomised controlled trial to compare the diagnostic yield of Positron Emission Tomography Computed Tomography (PET-CT) TARGETed pleural biopsy versus CT-guided pleural biopsy in suspected pleural malignancy
TEMPLATE A Randomised Controlled Trial Investigating the Pharmacodynamic Effect of Ticagrelor Monotherapy on Platelet Reactivity in Patients with Coronary Artery Disease: The TEMPLATE Study
TEST TEST (Trial of Eczema allergy Screening Tests) is a feasibility study to help determine if routine allergy tests can help treatment of children with eczema.
THERMIC2 A Randomised Controlled Trial to Compare Normothermic Versus Hypothermic Cardiopulmonary Bypass in Children Undergoing Open Heart Surgery 
THERMIC3 Intermittent Antegrade Warm Blood versus Cold Blood Cardioplegia in Children Undergoing Open Heart Surgery: A Prospective, Multicentre, Randomised Controlled Trial 
Travel to Work The effectiveness and cost effectiveness of an employer-led intervention to increase walking during the daily commute: Cluster randomised controlled trial.  See outputs to this study.
TITRE2 A multi-centre randomised controlled trial of Transfusion Indication Threshold Reduction on transfusion rates, morbidity and healthcare resource use following cardiac surgery 
TRIUMPH TReating Urinary symptoms in Men in Primary Healthcare
VERDICT Preoperative Volume Replacement vs. usual care in Diabetic patients having CABG surgery: a randomised controlled trial
VICI Clinical efficacy and mechanistic evaluation of Eplerenone for central serous chorio-retinopathy – the VICI randomised trial 
VICTORY Prospective, randomised, controlled investigation comparing the safety and performance of 032-11 surgical haemostat 2g applicator with FLOSEAL hemostatic matrix as an adjunctive haemostat in cardiac surgery and thoracic surgery 
VIOLET Video Assisted Thoracoscopic Lobectomy Versus Conventional Open Lobectomy For Lung Cancer, A Multi-Centre Randomised Controlled Trial With An Internal Pilot
UNBLOCS   A randomised controlled trial to determine the clinical and cost effectiveness of thulium laser transurethral vaporesection of the prostate (ThuVARP) versus transurethral resection of the prostate (TURP) in the National Health Service (NHS) 
WISE A cluster randomised controlled trial evaluating an intervention to improve the mental health support and training available to secondary school teachers