Association of non-coding RNAs with Coronary Artery Disease and type 2 Diabetes
Status: In Follow Up
Sponsor: University Hospitals Bristol
REC Number: 13/LO/1687
Genes hold the information to build and maintain the human body. They contain the code to produce proteins which perform many functions within our body. However, genes do not do this alone and instead rely on the help of other molecules. Recently, scientists have discovered the existence of chemicals called “non-coding” ribonucleic acids (ncRNAs). These chemicals may influence the production of proteins and have an important role in the heart; some of them can aggravate heart conditions while others can have positive effects. The levels of these chemicals, which are present in the tissues and fluid of the body, may be possible indicators of disease or of the effects of heart surgery.
In Arcadia we are asking participants who undergo cardiac surgery to provide heart biopsies and blood and urine samples, and allow us to use tissue samples left over from surgery. We are measuring and identifying all non-coding RNAs in these tissues and determining whether their levels are affected by heart disease and diabetes. The study also aims to find out whether we can measure the ncRNAs in blood, urine and tissue of patients undergoing heart surgery, to predict which patients will develop complications. This study is important because it could help identify treatments to improve the recovery of the patients after heart surgery.
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Chief Investigator: Prof. Gianni Angelini
Study coordinator: Rachael Heys (Bristol Royal Infirmary), Alima Rahman (Hammersmith Hospital)